Kosher and Halal Certified Camptotheca Extract

• Certification: BRC, ISO, FDA, HACCP, SGS, Kosher Halal
• Assay Method: HPLC, UV
• Application Form: Injection, Lotion, Suppository, Paste, Tablet, Capsule
• Application: Food, Health Care Products, Medicine
• State: Powder
• Extract Source: Camptotheca
• Model NO.: Extract
• Product Name: Camptotheca Extract
• Appearance: Light Yellow Crystalline Powder
• Used Part: Leaf
• Test Method: HPLC/UV
• Shelf Life: 2 Years
• Transport Package: Drum/Carton
• Specification: 25kg/Drum
• Trademark: VNI
• Origin: Shandong
• HS Code: 2932999099
• Production Capacity: 500, 000 Kg/Year

Product Description

Product Description

 

Camptothecin Extract Series:

CAS  7689-03-4         camptothecin

CAS# 78287-27-1      7-ethyl-camptothecin

CAS# 64439-81-2       10-hydrocamptothecin

CAS# 130194-92-2     7-Ethyl-10-hydroxycamptothecin

Product Name	Camptotheca Extract
Other name	(S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
Used Part	Leaf
Specification	98%
Appearance	Light yellow crystalline powder
CAS NO.	78287-27-1
Test Method	HPLC
Extraction type	Solvent Extraction
Molecular Formula	C22H20N2O4
Molecular Weight	376.40
Shelf life	2 years

1. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
2. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
3. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.
4. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.