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| Certification: | ISO, FDA, HACCP, SGS, Kosher Halal |
| Assay Method: | HPLC, UV |
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Plectranthus barbatus, or more commonly known as Coleus forskohlii and Indian Coleus (other synonyms: C. barbatus Benth., Plectranthus forskohlii Willd., and P. comosus Willemse), , a member of the mint family, is a tropical perennial plant related to the typical coleus species. This species is a perennial herb with fleshy, fibrous roots that grows wild in the warm subtropical temperate areas in India, Burma, Thailand, and South-West China (Yunnan Province). In India, it is cultivated for use as a condiment. Coleus forskohlii is an important traditional Ayurvedic herb that has been a part of Indian medicine for centuries. For centuries, in Ayurvedic medicine, Coleus species have been used to treat various diseases such as hypothyroidism, heart disease, respiratory disorders (asthma), convulsions, spasmodic pain and painful urination.
In recent years, Coleus forskohlii has gained recognition as the only known plant source of the diterpene, forskohlin (Forlean as its patented name), and it is interesting from a scientific and medicinal standpoint because it produces forskolin. In the 1970s researchers isolated a unique chemically active extract from the Coleus forskohlii roots and called it forskolin, which is a labdane diterpene. In addition to forskolin, this herb has labdane diterpene glycosides forskoditerpenosides A, B, C, D, and E. Additional compounds include 14-deoxycoleon U, coleonol, alpha-amyrin, demethylcryptojaponol, betulic acid, alpha-cedrol and beta-sitosterol. Now available in supplement form, coleus forskohlii extract has been tested in a number of conditions.
Effects on Cyclic AMP: Increased cellular cyclic AMP results in inhibition of platelet activation, decreased likelihood of blood clots, reduced release of histamine, decreased allergy symptoms, increased force of contraction of the heart, relaxation of the arteries and other smooth muscles, increased thyroid function, increased fat metabolism, increased energy and possibly weight loss. Cyclic AMP and the chemicals it activates comprise a second messenger system that is responsible for carrying out the complex and powerful effects of hormones in the body. In addition, asthma, eczema, psoriasis, angina, obesity and hypertension are believed to be associated with decreased Cyclic AMP.
Treat Glaucoma: Glaucoma is a condition in which the pressure in the eye is too high, due to an imbalance between the formation of aqueous humor in the eye and its absorption in or drainage out of the eye. Eventually, as the pressure builds up, the blood vessels nourishing the optic nerve are constricted, resulting in irreversible damage to the nerve and impaired vision culminating in blindness, if left untreated. There are several treatments that may be beneficial and coleus is one of them. Clinical studies have shown that topical application of one percent forskolin eye drops resulted in significant decreases in intraocular pressure for up to five hours. Limited clinical experience suggests that oral forskolin appears to offer significant potential for sufferers of glaucoma. An Indian pharmaceutical company is currently engaged in clinical trials of a forskolin eye drop product.
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