Kosher Cerified 100% Natural Chuan Wu Extract

• Certification: RoHS, BRC, ISO, FDA, HACCP, SGS, Kosher Halal
• Assay Method: HPLC, UV
• Application Form: Injection, Lotion, Suppository, Paste, Tablet, Capsule
• Application: Food, Health Care Products, Medicine
• State: Powder
• Extract Source: Aconite Root
• Model NO.: Extract
• Product Name: Aconitum Root Extract
• Appearance: Brown Powder
• Latin Name: Radix Aconiti
• Shelf Life: 2years
• Ash Content: <5.0%
• Transport Package: Drum/Carton
• Specification: 25kg/Drum
• Trademark: VNI
• Origin: Shandong
• HS Code: 2932999099
• Production Capacity: 500, 000 Kg/Year

Product Description

Hypaconitine (HA), an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism. Little is known about the hepatic cytochrome P450-catalyzed metabolism of HA. The present study investigated the metabolism of HA in vitro using male human liver microsomes (MHLMS). The results of chemical inhibition, monoclonal antibody inhibition, and cDNA-expressed CYP enzyme studies showed that the primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6, and CYP2E1. CYP1A2 and 2C8 provided minor contributions.

Product Name	Aconitum Root Extract
Specification	98%
Test Method	HPLC
Storage Condition	Store in cool & dry place, Keep away from strong light and heat.

 

Appearance	Brown Powder
Order	Characteristic
Loss on Dring	<5.0%
Ash Content	<5.0%

1. Hypaconitine (HA), an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism, the hepatic cytochrome P450-catalyzed metabolism of HA.

2. Hypaconitine and aconitine produce neuromuscular blockade by reducing the evoked quantal release, the mechanism of this effect was attributed mainly to blocking of the nerve compound action potential.

3. Hypaconitine induces QT prolongation, mediated through inhibition of KCNH2 (hERG) potassium channels in conscious dogs.

4. Hypaconitine has anti-inflammatory activity.

5. Hypaconitine can inhibit CaM expression and Cx43 (Ser368) phosphorylation, and liquiritin can interfere with this kind of effect by synergistically inhibiting CaM expression and by antagonizing Cx43 (Ser368) dephosphorylation induced by hypaconitine.

Package

 

FAQ

1. Sample 
50-100g free sample could offered to you to test the quality;

2. MOQ
1KG pack in aluminum foil bag;

3. Common Package
25kgs/Drum, 20kgs /Carton, 1kg/Bag etc;

4. Deliver Lead Time
It is about 2-3days after payment or order confirmed;

5. Payment
Payment could be done by T/T, Western union, Paypal, L/C or Banks indomestic.

6. Discount
Price is determined by Quantity, large quantity with lower prices.